› 2q3h

X-ray diffraction
1.73Å resolution

The crystal structure of RhouA in the GDP-bound state.

Released:
DOI: 10.2210/pdb2q3h/pdb
PDB entry 2q3h coloured by chain, front view.
PDB entry 2q3h coloured by chain, side view.
PDB entry 2q3h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gileadi C, Yang X, Papagrigoriou E, Elkins J, Zhao Y, Bray J, Gileadi O, Umeano C, Ugochukwu E, Uppenberg J, Bunkoczi G, von Delft F, Pike ACW, Phillips C, Savitsky P, Fedorov O, Edwards A, Weigelt J, Arrowsmith CH, Sundstrom M, Doyle DA, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho-related GTP-binding protein RhoU Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 21.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L0Q8 (Residues: 32-230; Coverage: 77%)
Gene names: ARHU, CDC42L1, G28K, RHOU, SB128, WRCH1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 82.068Å b: 53.6Å c: 54.128Å
α: 90° β: 118.8° γ: 90°
R-values:
R R work R free
0.183 0.183 0.222
Expression system: Escherichia coli

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