› 2q3y

X-ray diffraction
2.4Å resolution

Ancestral Corticiod Receptor in Complex with DOC

Released:
DOI: 10.2210/pdb2q3y/pdb
PDB entry 2q3y coloured by chain, front view.
PDB entry 2q3y coloured by chain, side view.
PDB entry 2q3y coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW
Science 317 1544-8 (2007)
PMID: 17702911

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163188 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ancestral Corticiod Receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.94 KDa
Source organism: unidentified
Expression system: Escherichia coli
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 0 group B member 2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15466 (Residues: 18-27; Coverage: 4%)
Gene names: NR0B2, SHP

Ligands and Environments

2 bound ligands:
Ligand 1CA 1 x 1CA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P43212
Unit cell:
a: 78.995Å b: 78.995Å c: 112.467Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.24
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

54 review citations

Convergence, adaptation, and constraint.
Losos JB. (2011)
53 more

6 mentions without citation

Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund et al. (2007)
5 more