› 2qib

X-ray diffraction
1.7Å resolution

Crystal structure of tetR-family transcriptional regulator from Streptomyces coelicolor

Released:
DOI: 10.2210/pdb2qib/pdb
PDB entry 2qib coloured by chain, front view.
PDB entry 2qib coloured by chain, side view.
PDB entry 2qib coloured by chain, top view.
Source organism: Streptomyces coelicolor A3(2)
Entry authors: Zhang R, Xu X, Zheng H, Savchenko A, Edwards A, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 25.74 KDa
Source organism: Streptomyces coelicolor A3(2)
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9KZ14 (Residues: 1-230; Coverage: 100%)
Gene names: SC10B7.18, SCO2223
Sequence domains: Bacterial regulatory proteins, tetR family
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

1 bound ligand:
Ligand P6G 4 x P6G
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 54.607Å b: 76.292Å c: 65.262Å
α: 90° β: 107.54° γ: 90°
R-values:
R R work R free
0.179 0.177 0.214
Expression system: Escherichia coli BL21

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