› 2qkr

X-ray diffraction
2.6Å resolution

Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound

Released:
DOI: 10.2210/pdb2qkr/pdb
PDB entry 2qkr coloured by chain, front view.
PDB entry 2qkr coloured by chain, side view.
PDB entry 2qkr coloured by chain, top view.
Source organism: Cryptosporidium parvum Iowa II
Entry authors: Wernimont AK, Dong A, Lew J, Lin YH, Hassanali A, Arrowsmith CH, Edwards AM, Weigelt J, Sundstrom M, Bochkarev A, Hui R, Artz JD, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176922 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 homolog Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.09 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CRJ8 (Residues: 1-295; Coverage: 100%)
Gene name: cgd5_2510
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IXM 1 x IXM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P43212
Unit cell:
a: 64.133Å b: 64.133Å c: 201.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.3
Expression system: Escherichia coli

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