› 2qlu

X-ray diffraction
2Å resolution

Crystal structure of Activin receptor type II kinase domain from human

Released:
DOI: 10.2210/pdb2qlu/pdb
PDB entry 2qlu coloured by chain, front view.
PDB entry 2qlu coloured by chain, side view.
PDB entry 2qlu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution.
Han S, Loulakis P, Griffor M, Xie Z
Protein Sci 16 2272-7 (2007)
PMID: 17893364

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activin receptor type-2B Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 35.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13705 (Residues: 190-487; Coverage: 60%)
Gene name: ACVR2B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand ADE 1 x ADE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P43212
Unit cell:
a: 98.217Å b: 98.217Å c: 71.345Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.283

Quick links

Citations

5 review citations

Oligomeric interactions of TGF-β and BMP receptors.
Ehrlich et al. (2012)
4 more

17 mentions without citation

Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family.
Kim et al. (2019)
16 more