› 2qnk

X-ray diffraction
1.6Å resolution

Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase

Released:
DOI: 10.2210/pdb2qnk/pdb
PDB entry 2qnk coloured by chain, front view.
PDB entry 2qnk coloured by chain, side view.
PDB entry 2qnk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bitto E, Bingman CA, Wesenberg GE, Phillips Jr GN, Center for Eukaryotic Structural Genomics (CESG)

Function and Biology Details

Reaction catalysed: 
3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxyanthranilate 3,4-dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 32.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46952 (Residues: 2-286; Coverage: 100%)
Gene name: HAAO
Sequence domains: 3-hydroxyanthranilic acid dioxygenase
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand NI 1 x NI
Ligand PO4 1 x PO4
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 50.498Å b: 78.227Å c: 85.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.157 0.176
Expression system: Escherichia coli

Quick links