Function and Biology Details
Reaction catalysed:
Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH = 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Acyl transferase
- Polyketide synthase, beta-ketoacyl synthase domain
- Thiolase-like
- Malonyl-CoA ACP transacylase, ACP-binding
- Acyl transferase domain superfamily
- Acyl transferase/acyl hydrolase/lysophospholipase
- Polyketide synthase, C-terminal extension
- Beta-ketoacyl synthase, C-terminal
2 more domains
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
Molecule details ›
Chains: A, B
Length: 915 amino acids
Theoretical weight: 96.69 KDa
Source organism: Saccharopolyspora erythraea
Expression system: Escherichia coli BL21
UniProt:
Sequence domains:
Length: 915 amino acids
Theoretical weight: 96.69 KDa
Source organism: Saccharopolyspora erythraea
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q03132 (Residues: 27-922; Coverage: 25%)
Sequence domains:
- Beta-ketoacyl synthase, N-terminal domain
- Beta-ketoacyl synthase, C-terminal domain
- Ketoacyl-synthetase C-terminal extension
- Acyl transferase domain
