› 2qoq

X-ray diffraction
1.6Å resolution

Human EphA3 kinase and juxtamembrane region, base, AMP-PNP bound structure

Released:
DOI: 10.2210/pdb2qoq/pdb
PDB entry 2qoq coloured by chain, front view.
PDB entry 2qoq coloured by chain, side view.
PDB entry 2qoq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3).
Davis TL, Walker JR, Loppnau P, Butler-Cole C, Allali-Hassani A, Dhe-Paganon S
Structure 16 873-84 (2008)
PMID: 18547520

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 42.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ANP 1 x ANP
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 54.043Å b: 38.324Å c: 76.514Å
α: 90° β: 102.33° γ: 90°
R-values:
R R work R free
0.19 0.189 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Structure and function of VEGF receptors.
Stuttfeld et al. (2009)
12 more

4 mentions without citation

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms.
Lisabeth et al. (2012)
3 more