› 2qpy

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148492 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 251 amino acids
Theoretical weight: 29.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19091 (Residues: 649-899; Coverage: 28%)
Gene names: Ar, Nr3c4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.27 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q61026 (Residues: 744-753; Coverage: 1%)
Gene names: Grip1, Ncoa2, Src2, Tif2

Ligands and Environments

2 bound ligands:
Ligand DHT 1 x DHT
Ligand 4HY 1 x 4HY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 53.79Å b: 66.68Å c: 72.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.269 0.269
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

55 review citations

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
54 more

6 mentions without citation

A surface on the androgen receptor that allosterically regulates coactivator binding.
Estébanez-Perpiñá et al. (2007)
5 more