2qqk

X-ray diffraction
2.75Å resolution

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-208108 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neuropilin-2 Chain: A
Molecule details ›
Chain: A
Length: 579 amino acids
Theoretical weight: 65.39 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60462 (Residues: 23-595; Coverage: 63%)
Gene names: NRP2, VEGF165R2
Sequence domains:
Structure domains:
Antibody Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 231 amino acids
Theoretical weight: 24.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Antibody Light Chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 148.277Å b: 105.873Å c: 92.4Å
α: 90° β: 98.83° γ: 90°
R-values:
R R work R free
0.189 0.186 0.243
Expression systems:
  • Trichoplusia ni
  • Escherichia coli