› 2qs6

X-ray diffraction
3.08Å resolution

Structure of a Hoogsteen antiparallel duplex with extra-helical thymines

Released:
DOI: 10.2210/pdb2qs6/pdb
PDB entry 2qs6 coloured by chain, front view.
PDB entry 2qs6 coloured by chain, side view.
PDB entry 2qs6 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Stabilization by extra-helical thymines of a DNA duplex with Hoogsteen base pairs.
Pous J, Urpí L, Subirana JA, Gouyette C, Navaza J, Campos JL
J Am Chem Soc 130 6755-60 (2008)
PMID: 18447354

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115811 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*DAP*DTP*DAP*DTP*DAP*DTP*DCP*DT)-3') Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Length: 8 nucleotides
Theoretical weight: 2.4 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16
Spacegroup: C2
Unit cell:
a: 120.836Å b: 39.54Å c: 71.753Å
α: 90° β: 95.08° γ: 90°
R-values:
R R work R free
0.214 0.207 0.29
Expression system: Not provided

Quick links

Citations

2 review citations

Conformational changes of non-B DNA.
Choi et al. (2011)
1 more

2 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
1 more