› 2qsq

X-ray diffraction
1.95Å resolution

Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA)

Released:
DOI: 10.2210/pdb2qsq/pdb
PDB entry 2qsq coloured by chain, front view.
PDB entry 2qsq coloured by chain, side view.
PDB entry 2qsq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation.
Korotkova N, Yang Y, Le Trong I, Cota E, Demeler B, Marchant J, Thomas WE, Stenkamp RE, Moseley SL, Matthews S
Mol Microbiol 67 420-34 (2008)
PMID: 18086185

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carcinoembryonic antigen-related cell adhesion molecule 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06731 (Residues: 34-144; Coverage: 17%)
Gene names: CEA, CEACAM5
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: R3
Unit cell:
a: 132.531Å b: 132.531Å c: 82.762Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.18 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Molecular mechanisms of Escherichia coli pathogenicity.
Croxen et al. (2010)
8 more

13 mentions without citation

Methods and Applications of In Silico Aptamer Design and Modeling.
Buglak et al. (2020)
12 more