› 2qtw

X-ray diffraction
1.9Å resolution

The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain

Released:
DOI: 10.2210/pdb2qtw/pdb
PDB entry 2qtw coloured by chain, front view.
PDB entry 2qtw coloured by chain, side view.
PDB entry 2qtw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Hampton EN, Knuth MW, Li J, Harris JL, Lesley SA, Spraggon G
Proc Natl Acad Sci U S A 104 14604-9 (2007)
PMID: 17804797

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185469 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 29-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 546 amino acids
Theoretical weight: 58.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 62.427Å b: 70.149Å c: 148.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.239
Expression system: Homo sapiens

Quick links

Citations

29 review citations

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease.
Abifadel et al. (2009)
28 more

13 mentions without citation

Molecular basis for LDL receptor recognition by PCSK9.
Kwon et al. (2008)
12 more