› 2qvk

X-ray diffraction
1.45Å resolution

The second Ca2+-binding domain of the Na+-Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis

Released:
DOI: 10.2210/pdb2qvk/pdb
PDB entry 2qvk coloured by chain, front view.
PDB entry 2qvk coloured by chain, side view.
PDB entry 2qvk coloured by chain, top view.
Source organism: Canis lupus familiaris
Primary publication:
The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.
Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J
Proc Natl Acad Sci U S A 104 18467-72 (2007)
PMID: 17962412

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.65 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P23685 (Residues: 533-721; Coverage: 20%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1, null
Spacegroup: P21212
Unit cell:
a: 82.336Å b: 76.491Å c: 22.538Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.161 0.192
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Khananshvili D. (2013)
14 more

2 mentions without citation

Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.
Hilge M. (2012)
1 more