› 2qz4

X-ray diffraction
2.22Å resolution

Human paraplegin, AAA domain in complex with ADP

Released:
DOI: 10.2210/pdb2qz4/pdb
PDB entry 2qz4 coloured by chain, front view.
PDB entry 2qz4 coloured by chain, side view.
PDB entry 2qz4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.
Karlberg T, van den Berg S, Hammarström M, Sagemark J, Johansson I, Holmberg-Schiavone L, Schüler H
PLoS One 4 e6975 (2009)
PMID: 19841671

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial inner membrane m-AAA protease component paraplegin Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UQ90 (Residues: 305-565; Coverage: 33%)
Gene names: CAR, CMAR, PGN, SPG7
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P4322
Unit cell:
a: 57.2Å b: 57.2Å c: 155.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.262
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Mitochondrial matrix proteases as novel therapeutic targets in malignancy.
Goard et al. (2014)
5 more

8 mentions without citation

Multifunctional Mitochondrial AAA Proteases.
Glynn SE. (2017)
7 more