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Functional architecture of the retromer cargo-recognition complex

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: retrograde transport, endosome to Golgi
Cellular component: retromer, cargo-selective complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03635
Domain description: Vacuolar protein sorting-associated protein 35
Occurring in:
  1. Vacuolar protein sorting-associated protein 35
The deposited structure of PDB entry 2r17 contains 2 copies of Pfam domain PF03635 (Vacuolar protein sorting-associated protein 35) in Vacuolar protein sorting-associated protein 35. Showing 1 copy in chain C.

PF12850
Domain description: Calcineurin-like phosphoesterase superfamily domain
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
The deposited structure of PDB entry 2r17 contains 2 copies of Pfam domain PF12850 (Calcineurin-like phosphoesterase superfamily domain) in Vacuolar protein sorting-associated protein 29. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005378
Domain description: Vacuolar protein sorting-associated protein 35
Occurring in:
  1. Vacuolar protein sorting-associated protein 35
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
IPR000979
Domain description: Phosphodiesterase MJ0936/Vps29
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
IPR042491
Domain description: Vacuolar protein sorting-associated protein 35, C-terminal
Occurring in:
  1. Vacuolar protein sorting-associated protein 35
IPR028661
Domain description: Vacuolar protein sorting-associated protein 29
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
IPR024654
Domain description: Calcineurin-like phosphoesterase domain, lpxH-type
Occurring in:
  1. Vacuolar protein sorting-associated protein 29

Structure domains

CATH CATH domains
1.25.40.660
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C
Occurring in:
  1. Vacuolar protein sorting-associated protein 35
The deposited structure of PDB entry 2r17 contains 2 copies of CATH domain 1.25.40.660 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Vacuolar protein sorting-associated protein 35. Showing 1 copy in chain C.
3.60.21.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Purple Acid Phosphatase; chain A, domain 2
Homology: Purple Acid Phosphatase; chain A, domain 2
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
The deposited structure of PDB entry 2r17 contains 2 copies of CATH domain 3.60.21.10 (Purple Acid Phosphatase; chain A, domain 2) in Vacuolar protein sorting-associated protein 29. Showing 1 copy in chain A.
SCOP SCOP annotation
111233
Class: Alpha and beta proteins (a+b)
Fold: Metallo-dependent phosphatases
Superfamily: Metallo-dependent phosphatases
Occurring in:
  1. Vacuolar protein sorting-associated protein 29
The deposited structure of PDB entry 2r17 contains 2 copies of SCOP domain 111233 (YfcE-like) in Vacuolar protein sorting-associated protein 29. Showing 1 copy in chain A.

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