› 2r1d

X-ray diffraction
2.6Å resolution

Crystal structure of rat neurexin 1beta in the Ca2+ containing form

Released:
DOI: 10.2210/pdb2r1d/pdb
PDB entry 2r1d coloured by chain, front view.
PDB entry 2r1d coloured by chain, side view.
PDB entry 2r1d coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Regulation of neurexin 1beta tertiary structure and ligand binding through alternative splicing.
Shen KC, Kuczynska DA, Wu IJ, Murray BH, Sheckler LR, Rudenko G
Structure 16 422-31 (2008)
PMID: 18334217

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurexin-1-beta Chains: A, B, C, D, E, F, G, H, I, W
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, W
Length: 226 amino acids
Theoretical weight: 24.32 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q63373 (Residues: 47-302; Coverage: 54%)
Gene name: Nrxn1
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21212
Unit cell:
a: 116.683Å b: 195.719Å c: 103.867Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
7 more

6 mentions without citation

Neurexins.
Reissner et al. (2013)
5 more