› 2r1u

X-ray diffraction
1.5Å resolution

DJ-1 activation by catechol quinone modification

Released:
DOI: 10.2210/pdb2r1u/pdb
PDB entry 2r1u coloured by chain, front view.
PDB entry 2r1u coloured by chain, side view.
PDB entry 2r1u coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhongtao Z, Yue F

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99497 (Residues: 2-188; Coverage: 99%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P31
Unit cell:
a: 75.688Å b: 75.688Å c: 75.045Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.185 0.195
Expression system: Escherichia coli

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