› 2r2j

X-ray diffraction
2.6Å resolution

crystal structure of human ERp44

Released:
DOI: 10.2210/pdb2r2j/pdb
PDB entry 2r2j coloured by chain, front view.
PDB entry 2r2j coloured by chain, side view.
PDB entry 2r2j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail.
Wang L, Wang L, Vavassori S, Li S, Ke H, Anelli T, Degano M, Ronzoni R, Sitia R, Sun F, Wang CC
EMBO Rep 9 642-7 (2008)
PMID: 18552768

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmic reticulum resident protein 44 Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 44.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BS26 (Residues: 30-406; Coverage: 100%)
Gene names: ERP44, KIAA0573, TXNDC4, UNQ532/PRO1075
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand SIN 1 x SIN
Ligand FMT 2 x FMT
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P3121
Unit cell:
a: 83.501Å b: 83.501Å c: 123.137Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.263
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation.
Hatahet et al. (2009)
15 more

7 mentions without citation

'Something in the way she moves': The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI).
Freedman et al. (2017)
6 more