› 2r30

X-ray diffraction
3.2Å resolution

Crystal Structure of human GITRL mutant

Released:
DOI: 10.2210/pdb2r30/pdb
PDB entry 2r30 coloured by chain, front view.
PDB entry 2r30 coloured by chain, side view.
PDB entry 2r30 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Chattopadhyay K, Ramagopal UA, Mukhopadhaya A, Malashkevich VN, Dilorenzo TP, Brenowitz M, Nathenson SG, Almo SC
Proc Natl Acad Sci U S A 104 19452-7 (2007)
PMID: 18040044

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193993 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 18 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UNG2 (Residues: 52-177; Coverage: 71%)
Gene names: AITRL, GITRL, TL6, TNFSF18, UNQ149/PRO175
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P63
Unit cell:
a: 72.21Å b: 72.21Å c: 52.937Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.18 0.239
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
12 more

1 mention without citation

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Chattopadhyay et al. (2007)