› 2r3n

X-ray diffraction
1.63Å resolution

Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

Released:
DOI: 10.2210/pdb2r3n/pdb
PDB entry 2r3n coloured by chain, front view.
PDB entry 2r3n coloured by chain, side view.
PDB entry 2r3n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-guided discovery of cyclin-dependent kinase inhibitors.
Fischmann TO, Hruza A, Duca JS, Ramanathan L, Mayhood T, Windsor WT, Le HV, Guzi TJ, Dwyer MP, Paruch K, Doll RJ, Lees E, Parry D, Seghezzi W, Madison V
Biopolymers 89 372-9 (2008)
PMID: 17937404

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.03 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SCZ 1 x SCZ
1 modified residue:
Ligand CSD 1 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P212121
Unit cell:
a: 53.2Å b: 70.62Å c: 71.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.235
Expression system: unidentified baculovirus

Quick links

Citations

4 review citations

Cyclin-dependent kinase inhibitors: a survey of recent patent literature.
Galons et al. (2010)
3 more

2 mentions without citation

Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl.
Paul et al. (2020)
1 more