› 2r4h

X-ray diffraction
2.05Å resolution

Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase

Released:
DOI: 10.2210/pdb2r4h/pdb
PDB entry 2r4h coloured by chain, front view.
PDB entry 2r4h coloured by chain, side view.
PDB entry 2r4h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Pilka ES, Hozjan V, Kavanagh KL, Cooper C, Pike ACW, Elkins JM, Doyle DA, von Delft F, Sundstrom M, Arrowsmith CH, Weigelt J, Edwards AM, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 112 amino acids
Theoretical weight: 12.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96QZ7 (Residues: 1149-1233; Coverage: 6%)
Gene names: AIP3, BAIAP1, BAP1, MAGI1, TNRC19
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand HIS 5 x HIS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 40.052Å b: 77.759Å c: 50.182Å
α: 90° β: 101.49° γ: 90°
R-values:
R R work R free
0.191 0.188 0.258
Expression system: Escherichia coli

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