› 2r6y

X-ray diffraction
2Å resolution

Estrogen receptor alpha ligand-binding domain in complex with a SERM

Released:
DOI: 10.2210/pdb2r6y/pdb
PDB entry 2r6y coloured by chain, front view.
PDB entry 2r6y coloured by chain, side view.
PDB entry 2r6y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, Griffin PR
Proc Natl Acad Sci U S A 105 7171-6 (2008)
PMID: 18474858

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 28.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 304-551; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand LLC 2 x LLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: C2221
Unit cell:
a: 63.132Å b: 98.737Å c: 174.981Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.271
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action.
Shanle et al. (2011)
7 more

9 mentions without citation

Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands.
Ng et al. (2014)
8 more