› 2ra4

X-ray diffraction
1.7Å resolution

Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)

Released:
DOI: 10.2210/pdb2ra4/pdb
PDB entry 2ra4 coloured by chain, front view.
PDB entry 2ra4 coloured by chain, side view.
PDB entry 2ra4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).
Barinka C, Prahl A, Lubkowski J
Acta Crystallogr D Biol Crystallogr 64 273-8 (2008)
PMID: 18323622

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-189231 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99616 (Residues: 24-98; Coverage: 92%)
Gene names: CCL13, MCP4, NCC1, SCYA13
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

2 bound ligands:
Ligand SO4 6 x SO4
Ligand TFA 1 x TFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I4
Unit cell:
a: 74.673Å b: 74.673Å c: 51.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.216
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The multiple faces of CCL13 in immunity and inflammation.
Mendez-Enriquez et al. (2013)
1 more

9 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
8 more