› 2ren

X-ray diffraction
2.5Å resolution

STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb2ren/pdb
PDB entry 2ren coloured by chain, front view.
PDB entry 2ren coloured by chain, side view.
PDB entry 2ren coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN
Science 243 1346-51 (1989)
PMID: 2493678

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I4
Unit cell:
a: 134.08Å b: 134.08Å c: 41.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 not available not available
Expression system: Not provided

Quick links

Citations

25 review citations

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes.
Khan et al. (1998)
24 more

8 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
7 more