› 2rew

X-ray diffraction
2.35Å resolution

Crystal Structure of PPARalpha ligand binding domain with BMS-631707

Released:
DOI: 10.2210/pdb2rew/pdb
PDB entry 2rew coloured by chain, front view.
PDB entry 2rew coloured by chain, side view.
PDB entry 2rew coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Muckelbauer J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07869 (Residues: 196-468; Coverage: 58%)
Gene names: NR1C1, PPAR, PPARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand CPQ 1 x CPQ
Ligand REW 1 x REW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3121
Unit cell:
a: 78.264Å b: 78.264Å c: 98.715Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.245
Expression system: Escherichia coli BL21(DE3)

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