› 2rf0

X-ray diffraction
2Å resolution

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Released:
DOI: 10.2210/pdb2rf0/pdb
PDB entry 2rf0 coloured by chain, front view.
PDB entry 2rf0 coloured by chain, side view.
PDB entry 2rf0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Eswaran J, Elkins J, Keates T, Pike ACW, Berridge G, Savitsky P, Sundstrom M, Arrowsmith CH, Weigelt J, Edwards AM, von Delft F, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 89 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02779 (Residues: 13-78; Coverage: 7%)
Gene names: MAP3K10, MLK2, MST
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3212
Unit cell:
a: 69.68Å b: 69.68Å c: 103.98Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.23
Expression system: Escherichia coli

Quick links