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X-ray diffraction
2.9Å resolution

The Thrombospondin-1 Polymorphism Asn700Ser Associated with Cornoary Artery Disease Causes Local and Long-Ranging Changes in Protein Structure

Released:
DOI: 10.2210/pdb2rhp/pdb
PDB entry 2rhp coloured by chain, front view.
PDB entry 2rhp coloured by chain, side view.
PDB entry 2rhp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability.
Carlson CB, Liu Y, Keck JL, Mosher DF
J Biol Chem 283 20069-76 (2008)
PMID: 18499674

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Thrombospondin-2 Chain: A
Molecule details ›
Chain: A
Length: 622 amino acids
Theoretical weight: 69.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35442 (Residues: 551-1172; Coverage: 54%)
Gene names: THBS2, TSP2
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 30 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: I222
Unit cell:
a: 93.892Å b: 122.65Å c: 155.381Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.277
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

The thrombospondins.
Adams et al. (2011)
6 more

2 mentions without citation

Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability.
Carlson et al. (2008)
1 more