2riv

X-ray diffraction
1.5Å resolution

Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thyroxine-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05543 (Residues: 33-371; Coverage: 86%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Thyroxine-binding globulin Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05543 (Residues: 377-415; Coverage: 10%)
Gene names: SERPINA7, TBG

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21212
Unit cell:
a: 173.136Å b: 42.585Å c: 55.989Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.214
Expression system: Escherichia coli