› 2rmq

Solution NMR

Solution structure of fully modified 4'-thioDNA with the sequence of d(CGCGAATTCGCG)

Released:
DOI: 10.2210/pdb2rmq/pdb
PDB entry 2rmq coloured by chain, front view.
PDB entry 2rmq coloured by chain, side view.
PDB entry 2rmq coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Unexpected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance.
Matsugami A, Ohyama T, Inada M, Inoue N, Minakawa N, Matsuda A, Katahira M
Nucleic Acids Res 36 1805-12 (2008)
PMID: 18252770

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115836 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*(C4S)P*(S4G)P*(C4S)P*(S4G)P*(S4A)P*(S4A)P*(T49)P*(T49)P*(C4S)P*(S4G)P*(C4S)P*(S4G))-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.86 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
4 modified residues:
Ligand C4S 8 x C4S
Ligand S4G 8 x S4G
Ligand S4A 4 x S4A
Ligand T49 4 x T49

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

[Development of highly nuclease-resistant chemically-modified oligonucleotides].
Matsuda A. (2011)
5 other articles

2 mentions without citation

The many twists and turns of DNA: template, telomere, tool, and target.
Egli et al. (2010)
1 more