› 2rop

Solution NMR

Solution structure of domains 3 and 4 of human ATP7B

Released:
DOI: 10.2210/pdb2rop/pdb
PDB entry 2rop coloured by chain, ensemble of 20 models, front view.
PDB entry 2rop coloured by chain, ensemble of 20 models, side view.
PDB entry 2rop coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1.
Banci L, Bertini I, Cantini F, Rosenzweig AC, Yatsunyk LA
Biochemistry 47 7423-9 (2008)
PMID: 18558714

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WND/140 kDa Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 21.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35670 (Residues: 238-439; Coverage: 14%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Metabolism and functions of copper in brain.
Scheiber et al. (2014)
14 more

14 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
13 more