› 2roz

Solution NMR

Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode

Released:
DOI: 10.2210/pdb2roz/pdb
PDB entry 2roz coloured by chain, ensemble of 20 models, front view.
PDB entry 2roz coloured by chain, ensemble of 20 models, side view.
PDB entry 2roz coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.
Li H, Koshiba S, Hayashi F, Tochio N, Tomizawa T, Kasai T, Yabuki T, Motoda Y, Harada T, Watanabe S, Inoue M, Hayashizaki Y, Tanaka A, Kigawa T, Yokoyama S
J Biol Chem 283 27165-78 (2008)
PMID: 18650440

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146076 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C31 Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.84 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P12023 (Residues: 739-770; Coverage: 4%)
Gene names: A4, AD1, App
Sequence domains: Beta-amyloid precursor protein C-terminus
Amyloid beta precursor protein binding family B member 2 Chain: B
Molecule details ›
Chain: B
Length: 136 amino acids
Theoretical weight: 14.75 KDa
Source organism: Mus musculus
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: Q9DBR4 (Residues: 582-704; Coverage: 16%)
Gene names: Apbb2, Fe65l, Fe65l1
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: CELL-FREE SYNTHESIS

Quick links

Citations

3 review citations

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?
Beel et al. (2010)
2 more

5 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
4 more