› 2rpq

Solution NMR

Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3

Released:
DOI: 10.2210/pdb2rpq/pdb
PDB entry 2rpq coloured by chain, ensemble of 20 models, front view.
PDB entry 2rpq coloured by chain, ensemble of 20 models, side view.
PDB entry 2rpq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.
Sekiyama N, Ikegami T, Yamane T, Ikeguchi M, Uchimura Y, Baba D, Ariyoshi M, Tochio H, Saitoh H, Shirakawa M
J. Biol. Chem. 283 35966-75 (2008)
PMID: 18842587

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158460 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Small ubiquitin-related modifier 2 Chain: A
Molecule details ›
Chain: A
Length: 93 amino acids
Theoretical weight: 10.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61956 (Residues: 1-93; Coverage: 98%)
Gene names: SMT3B, SMT3H2, SUMO2
Sequence domains: Ubiquitin-2 like Rad60 SUMO-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Activating transcription factor 7-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 49 amino acids
Theoretical weight: 4.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6VMQ6 (Residues: 938-981; Coverage: 4%)
Gene names: ATF7IP, MCAF, MCAF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
Gareau et al. (2010)
5 more

4 mentions without citation

Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
Li et al. (2016)
3 more