› 2rrd

Solution NMR

Structure of HRDC domain from human Bloom syndrome protein, BLM

Released:
DOI: 10.2210/pdb2rrd/pdb
PDB entry 2rrd coloured by chain, ensemble of 20 models, front view.
PDB entry 2rrd coloured by chain, ensemble of 20 models, side view.
PDB entry 2rrd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the HRDC domain of human Bloom syndrome protein BLM.
Sato A, Mishima M, Nagai A, Kim SY, Ito Y, Hakoshima T, Jee JG, Kitano K
J Biochem 148 517-25 (2010)
PMID: 20739603

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RecQ-like DNA helicase BLM Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54132 (Residues: 1200-1295; Coverage: 7%)
Gene names: BLM, RECQ2, RECQL3
Sequence domains: HRDC domain
Structure domains: HRDC domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The BLM dissolvasome in DNA replication and repair.
Manthei et al. (2013)
4 more

4 mentions without citation

Structural mechanisms of human RecQ helicases WRN and BLM.
Kitano K. (2014)
3 more