› 2rv8

Solution NMR

Solution Structure of the PhoP DNA-Binding Domain from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb2rv8/pdb
PDB entry 2rv8 coloured by chain, ensemble of 30 models, front view.
PDB entry 2rv8 coloured by chain, ensemble of 30 models, side view.
PDB entry 2rv8 coloured by chain, ensemble of 30 models, top view.
Source organism: Mycobacterium tuberculosis CAS/NITR204
Primary publication:
Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis.
Macdonald R, Sarkar D, Amer BR, Clubb RT
J Biomol NMR 63 111-7 (2015)
PMID: 26209027

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Possible two component system response transcriptional positive regulator PhoP Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.72 KDa
Source organism: Mycobacterium tuberculosis CAS/NITR204
Expression system: Escherichia coli
UniProt:
  • Canonical: P71814 (Residues: 142-247; Coverage: 43%)
Gene names: Rv0757, phoP
Sequence domains: Transcriptional regulatory protein, C terminal
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Rapid addition of unlabeled silent solubility tags to proteins using a new substrate-fused sortase reagent.
Amer et al. (2016)

2 mentions without citation

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
Kim et al. (2017)
1 more