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TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT

Source organism: Rattus norvegicus
Biochemical function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological process: aromatic amino acid metabolic process
Cellular component: not assigned

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EC 1.14.16.2: Tyrosine 3-monooxygenase

Reaction catalysed:
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin
Systematic name:
L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Alternative Name(s):
  • L-tyrosine hydroxylase
  • Tyrosine 3-hydroxylase
  • Tyrosine hydroxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00351
Domain description: Biopterin-dependent aromatic amino acid hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
The deposited structure of PDB entry 2toh contains 1 copy of Pfam domain PF00351 (Biopterin-dependent aromatic amino acid hydroxylase) in Tyrosine 3-monooxygenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019774
Domain description: Aromatic amino acid hydroxylase, C-terminal
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR018301
Domain description: Aromatic amino acid hydroxylase, iron/copper binding site
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR041903
Domain description: Tyrosine 3-monooxygenase, catalytic domain
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR036329
Domain description: Aromatic amino acid monoxygenase, C-terminal domain superfamily
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR001273
Domain description: Aromatic amino acid hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR036951
Domain description: Aromatic amino acid hydroxylase superfamily
Occurring in:
  1. Tyrosine 3-monooxygenase

Structure domain

CATH CATH domain
1.10.800.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phenylalanine Hydroxylase
Homology: Aromatic amino acid hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
The deposited structure of PDB entry 2toh contains 1 copy of CATH domain 1.10.800.10 (Phenylalanine Hydroxylase) in Tyrosine 3-monooxygenase. Showing 1 copy in chain A.
SCOP SCOP annotation
56535
Class: Alpha and beta proteins (a+b)
Fold: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Occurring in:
  1. Tyrosine 3-monooxygenase
The deposited structure of PDB entry 2toh contains 1 copy of SCOP domain 56535 (Aromatic aminoacid monoxygenases, catalytic and oligomerization domains) in Tyrosine 3-monooxygenase. Showing 1 copy in chain A.

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