› 2trt

X-ray diffraction
2.5Å resolution

TETRACYCLINE REPRESSOR CLASS D

Released:
DOI: 10.2210/pdb2trt/pdb
PDB entry 2trt coloured by chain, front view.
PDB entry 2trt coloured by chain, side view.
PDB entry 2trt coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Hinrichs W, Kisker C, Düvel M, Müller A, Tovar K, Hillen W, Saenger W
Science 264 418-20 (1994)
PMID: 8153629

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142298 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tetracycline repressor protein class D Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 24.32 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0ACT4 (Residues: 2-218; Coverage: 100%)
Gene name: tetR
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand TAC 1 x TAC
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I4122
Unit cell:
a: 68.32Å b: 68.32Å c: 181.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 not available
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Proton-dependent multidrug efflux systems.
Paulsen et al. (1996)
35 more

12 mentions without citation

The TetR family of transcriptional repressors.
Ramos et al. (2005)
11 more