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CONFORMATIONAL CHANGES IN THE (ALA-84-VAL) MUTANT OF TUMOR NECROSIS FACTOR

X-ray diffraction
3.1Å resolution
PDB entry 2tun coloured by chain, front view.
PDB entry 2tun coloured by chain, side view.
PDB entry 2tun coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo hexamer
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Tumor necrosis factor, soluble form
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Multimeric state: homo hexamer
Accessible surface area: 34765.11 Å2
Buried surface area: 15722.53 Å2
Dissociation area: 879.9 Å2
Dissociation energy (ΔGdiss): -12.09 kcal/mol
Dissociation entropy (TΔSdiss): 13.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134294
Assembly 2 (preferred)
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Assembly Name: Soluble tumor necrosis factor complex
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Multimeric state: homo trimer
Accessible surface area: 18460.55 Å2
Buried surface area: 6948.15 Å2
Dissociation area: 3,474.08 Å2
Dissociation energy (ΔGdiss): 27.51 kcal/mol
Dissociation entropy (TΔSdiss): 25.35 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134285
Assembly 3
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Assembly Name: Soluble tumor necrosis factor complex
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Multimeric state: homo trimer
Accessible surface area: 18064.36 Å2
Buried surface area: 7014.58 Å2
Dissociation area: 3,507.29 Å2
Dissociation energy (ΔGdiss): 26.51 kcal/mol
Dissociation entropy (TΔSdiss): 25.35 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134285

Macromolecules

Tumor necrosis factor, soluble form
Chains: A, B, C, D, E, F
Length: 157 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls
SCOP: TNF-like
Tumor necrosis factor, soluble form in PDB entry 2tun, assembly 2, front view.
Tumor necrosis factor, soluble form in PDB entry 2tun, assembly 2, side view.
Tumor necrosis factor, soluble form in PDB entry 2tun, assembly 2, top view.
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