› 2tun

X-ray diffraction
3.1Å resolution

CONFORMATIONAL CHANGES IN THE (ALA-84-VAL) MUTANT OF TUMOR NECROSIS FACTOR

Released:
DOI: 10.2210/pdb2tun/pdb
PDB entry 2tun coloured by chain, front view.
PDB entry 2tun coloured by chain, side view.
PDB entry 2tun coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Saludjian P, Prange T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo hexamer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134285 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor, soluble form Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 157 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 166Å b: 166Å c: 93.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 not available not available
Expression system: Not provided

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