› 2uwi

X-ray diffraction
2Å resolution

Structure of CrmE, a poxvirus TNF receptor

Released:
DOI: 10.2210/pdb2uwi/pdb
PDB entry 2uwi coloured by chain, front view.
PDB entry 2uwi coloured by chain, side view.
PDB entry 2uwi coloured by chain, top view.
Source organism: Vaccinia virus Lister
Primary publication:
Structure of CrmE, a virus-encoded tumour necrosis factor receptor.
Graham SC, Bahar MW, Abrescia NG, Smith GL, Stuart DI, Grimes JM
J Mol Biol 372 660-71 (2007)
PMID: 17681535

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TNFR-Cys domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 142 amino acids
Theoretical weight: 15.87 KDa
Source organism: Vaccinia virus Lister
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8UYL3 (Residues: 22-153; Coverage: 79%)
Gene names: B28R, List195, crmE, m8259R, mO259R
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 41.38Å b: 56.49Å c: 122.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.
Smith et al. (2013)
10 more

5 mentions without citation

How vaccinia virus has evolved to subvert the host immune response.
Bahar et al. (2011)
4 more