› 2uwr

X-ray diffraction
1.34Å resolution

High resolution structure of human CD59

Released:
DOI: 10.2210/pdb2uwr/pdb
PDB entry 2uwr coloured by chain, front view.
PDB entry 2uwr coloured by chain, side view.
PDB entry 2uwr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structures of bacterially expressed soluble human CD59.
Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM
Acta Crystallogr Sect F Struct Biol Cryst Commun 63 648-52 (2007)
PMID: 17671359

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD59 glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13987 (Residues: 26-102; Coverage: 75%)
Gene names: CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 25.524Å b: 27.902Å c: 81.151Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.227
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
1 more

6 mentions without citation

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
Wickham et al. (2011)
5 more