› 2v12

X-ray diffraction
3.2Å resolution

Crystal Structure of Renin with Inhibitor 8

Released:
DOI: 10.2210/pdb2v12/pdb
PDB entry 2v12 coloured by chain, front view.
PDB entry 2v12 coloured by chain, side view.
PDB entry 2v12 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.
Rahuel J, Rasetti V, Maibaum J, Rüeger H, Göschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grütter MG
Chem Biol 7 493-504 (2000)
PMID: 10903938

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: C, O
Molecule details ›
Chains: C, O
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand C39 2 x C39
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: P213
Unit cell:
a: 142.9Å b: 142.9Å c: 142.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 not available
Expression system: Cricetulus griseus

Quick links

Citations

56 review citations

Renin inhibition with aliskiren: where are we now, and where are we going?
Azizi et al. (2006)
55 more

1 mention without citation

Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds.
Meshram et al. (2017)