› 2v5y

X-ray diffraction
3.1Å resolution

Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain

Released:
DOI: 10.2210/pdb2v5y/pdb
PDB entry 2v5y coloured by chain, front view.
PDB entry 2v5y coloured by chain, side view.
PDB entry 2v5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.
Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY
Science 317 1217-20 (2007)
PMID: 17761881

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151295 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase mu Chain: A
Molecule details ›
Chain: A
Length: 731 amino acids
Theoretical weight: 81.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P28827 (Residues: 21-742; Coverage: 50%)
Gene names: PTPRL1, PTPRM
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 7 x NAG
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 167.336Å b: 69.325Å c: 97.487Å
α: 90° β: 113.52° γ: 90°
R-values:
R R work R free
0.246 0.242 0.32
Expression system: Homo sapiens

Quick links

Citations

25 review citations

Interferon alpha as a primary pathogenic factor in human lupus.
Niewold TB. (2011)
24 more

13 mentions without citation

Receptor protein tyrosine phosphatases and cancer: new insights from structural biology.
Nikolaienko et al. (2012)
12 more