› 2v6h

X-ray diffraction
1.55Å resolution

Crystal structure of the C1 domain of cardiac myosin binding protein-C

Released:
DOI: 10.2210/pdb2v6h/pdb
PDB entry 2v6h coloured by chain, front view.
PDB entry 2v6h coloured by chain, side view.
PDB entry 2v6h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.
Govada L, Carpenter L, da Fonseca PC, Helliwell JR, Rizkallah P, Flashman E, Chayen NE, Redwood C, Squire JM
J Mol Biol 378 387-97 (2008)
PMID: 18374358

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172118 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin-binding protein C, cardiac-type Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14896 (Residues: 151-258; Coverage: 9%)
Gene name: MYBPC3
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: I41
Unit cell:
a: 48.848Å b: 48.848Å c: 95.132Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 not available 0.241
Expression system: Escherichia coli

Quick links

Citations

6 review citations

In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament.
Harris et al. (2011)
5 more

10 mentions without citation

Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C.
Craig et al. (2014)
9 more