› 2v7a

X-ray diffraction
2.5Å resolution

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Released:
DOI: 10.2210/pdb2v7a/pdb
PDB entry 2v7a coloured by chain, front view.
PDB entry 2v7a coloured by chain, side view.
PDB entry 2v7a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.
Modugno M, Casale E, Soncini C, Rosettani P, Colombo R, Lupi R, Rusconi L, Fancelli D, Carpinelli P, Cameron AD, Isacchi A, Moll J
Cancer Res 67 7987-90 (2007)
PMID: 17804707

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 33.14 KDa
Source organism: Homo sapiens
Expression system: Autographa
UniProt:
  • Canonical: P00519 (Residues: 227-512; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 627 2 x 627
Ligand MG 2 x MG
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P62
Unit cell:
a: 159.757Å b: 159.757Å c: 56.931Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.246
Expression system: Autographa

Quick links

Citations

32 review citations

Targeting cancer with small molecule kinase inhibitors.
Zhang et al. (2009)
31 more

13 mentions without citation

The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL.
Hantschel et al. (2012)
12 more