2vdq

X-ray diffraction
2.59Å resolution

Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-208770 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
Integrin alpha-IIb heavy chain Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 49.03 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-483; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 461 amino acids
Theoretical weight: 50.97 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-487; Coverage: 61%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:
Fibrinogen gamma chain Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02679 (Residues: 426-433; Coverage: 2%)
Gene names: FGG, PRO2061
MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.77 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 148.331Å b: 148.331Å c: 176.567Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.143 0.141 0.19
Expression systems:
  • Cricetulus griseus
  • Not provided