› 2vkw

X-ray diffraction
2.3Å resolution

Human NCAM, FN3 domains 1 and 2

Released:
DOI: 10.2210/pdb2vkw/pdb
PDB entry 2vkw coloured by chain, front view.
PDB entry 2vkw coloured by chain, side view.
PDB entry 2vkw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.
Carafoli F, Saffell JL, Hohenester E
J Mol Biol 377 524-34 (2008)
PMID: 18261743

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146666 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural cell adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13591 (Residues: 504-704; Coverage: 24%)
Gene names: NCAM, NCAM1
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P212121
Unit cell:
a: 52.77Å b: 71.346Å c: 98.217Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.272
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Rich et al. (2010)
5 more

6 mentions without citation

Chondroitin sulfate proteoglycans: structure-function relationship with implication in neural development and brain disorders.
Avram et al. (2014)
5 more