2vm6

X-ray diffraction
2.2Å resolution

Human Bcl2-A1 in complex with Bim-BH3 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-128965 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-related protein A1 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16548 (Residues: 1-149; Coverage: 85%)
Gene names: BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 3.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43521 (Residues: 141-165; Coverage: 13%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: R32
Unit cell:
a: 70.8Å b: 70.8Å c: 208.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.25
Expression system: Escherichia coli BL21(DE3)