› 2vm8

X-ray diffraction
1.9Å resolution

Human CRMP-2 crystallised in the presence of Mg

Released:
DOI: 10.2210/pdb2vm8/pdb
PDB entry 2vm8 coloured by chain, front view.
PDB entry 2vm8 coloured by chain, side view.
PDB entry 2vm8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2.
Majava V, Löytynoja N, Chen WQ, Lubec G, Kursula P
FEBS J 275 4583-96 (2008)
PMID: 18699782

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropyrimidinase-related protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 501 amino acids
Theoretical weight: 55.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16555 (Residues: 5-9, 10-490; Coverage: 85%)
Gene names: CRMP2, DPYSL2, ULIP2
Sequence domains: Amidohydrolase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P212121
Unit cell:
a: 86.51Å b: 126.24Å c: 209.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.256 0.325
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.
Hensley et al. (2011)
5 more

1 mention without citation

Structure of human collapsin response mediator protein 1: a possible role of its C-terminal tail.
Liu et al. (2015)