› 2vt4

X-ray diffraction
2.7Å resolution

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL

Released:
DOI: 10.2210/pdb2vt4/pdb
PDB entry 2vt4 coloured by chain, front view.
PDB entry 2vt4 coloured by chain, side view.
PDB entry 2vt4 coloured by chain, top view.
Source organism: Meleagris gallopavo
Primary publication:
Structure of a beta1-adrenergic G-protein-coupled receptor.
Warne T, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, Leslie AG, Tate CG, Schertler GF
Nature 454 486-91 (2008)
PMID: 18594507

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 35.75 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 31-368; Coverage: 64%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

4 bound ligands:
Ligand P32 4 x P32
Ligand NA 4 x NA
Ligand SOG 12 x SOG
Ligand D10 2 x D10
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 55.5Å b: 86.8Å c: 95.5Å
α: 67.6° β: 73.3° γ: 85.8°
R-values:
R R work R free
0.215 0.212 0.268
Expression system: Trichoplusia ni

Quick links

Citations

166 review citations

The structure and function of G-protein-coupled receptors.
Rosenbaum et al. (2009)
165 more

188 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
187 more